Role of polyplex charge density in lipopolyplexes-Reference-Cited by-同舟云学术

Role of polyplex charge density in lipopolyplexes

Published:2022 Issue:19 Volume:14 Page:7174-7180
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Huang Jianxiang¹,Song Wei¹,Meng Lijun¹,Shen Youqing²^ORCID,Zhou Ruhong¹³^ORCID

Affiliation:

1. Institute of Quantitative Biology, College of Life Sciences, and Department of Physics, Zhejiang University, Hangzhou 310027, China

2. College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China

3. Department of Chemistry, Columbia University, New York, NY10027, USA

Abstract

Molecular dynamics simulations elucidate the influence of polyplex charge density on the liposome self-assembly process at the atomic level, which provides a complementary approach to experiments for a better understanding of this promising gene therapy delivery system.

Funder

National Key Research and Development Program of China

Major Projects of Special Development Funds in Zhangjiang National Independent Innovation Demonstration Zone, Shanghai

Zhejiang University

W. M. Keck Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D1NR07897F

Reference34 articles.

1. Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination

2. mRNA vaccines — a new era in vaccinology

3. Non-viral vectors for gene-based therapy

4. Optimized polyethylenimine (PEI)-based nanoparticles for siRNA delivery, analyzed in vitro and in an ex vivo tumor tissue slice culture model

5. Gene therapy and DNA delivery systems