Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides

Author:

Mathieu Emilie12345ORCID,Bernard Anne-Sophie12345,Ching H. Y. Vincent12345,Somogyi Andrea678,Medjoubi Kadda678,Fores Jennifer Rodon12345,Bertrand Hélène C.12345ORCID,Vincent Amandine12345,Trépout Sylvain91051112ORCID,Guerquin-Kern Jean-Luc91051112ORCID,Scheitler Andreas13141516ORCID,Ivanović-Burmazović Ivana13141516,Seksik Philippe17451819,Delsuc Nicolas12345ORCID,Policar Clotilde12345ORCID

Affiliation:

1. Laboratoire des biomolécules

2. LBM

3. Département de chimie

4. Ecole normale supérieure

5. PSL University

6. Synchrotron SOLEIL

7. 91192 Gif sur Yvette

8. France

9. Institut Curie

10. Research Center

11. Chemistry

12. Modelling and Imaging for Biology (CMIB)

13. Department of Chemistry and Pharmacy

14. University of Erlangen-Nürnberg

15. 91058 Erlangen

16. Germany

17. Sorbonne Université

18. CNRS

19. INSERM

Abstract

A superoxide dismutase mimic was functionalized with three peptides: -R9, -RRWWRRWRR or -Fx-r-Fx-K (MPP). They were studied in intestinal epithelial cells in an inorganic cellular chemistry approach: quantification, distribution and bio-activity.

Funder

Agence Nationale de la Recherche

Association Francois Aupetit

Fondation pour la Recherche Médicale

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Reference62 articles.

1. Superoxide Dismutases and Superoxide Reductases

2. C. Policar , in Redox Active Therapeutics , ed. J. S. Reboucas , I. Batinic-Haberle , I. Spasojevic , D. S. Warner and D. St. Clair , Springer , 2016 , ch. 17, pp. 125–164

3. Mitochondrial disease in superoxide dismutase 2 mutant mice

4. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

5. Superoxide dismutase activities of an iron porphyrin and other iron complexes

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