Second-generation piperazine derivatives as promising radiation countermeasures

Author:

Chmil Vojtěch1ORCID,Živná Natálie23,Milanová Marcela1ORCID,Filipová Alžběta1ORCID,Pejchal Jaroslav2,Prchal Lukáš3,Muthná Darina4,Řeháček Vít5,Řezáčová Martina4ORCID,Marek Jan36,Tichý Aleš13ORCID,Havelek Radim4ORCID

Affiliation:

1. Department of Radiobiology, Military Faculty of Medicine, University of Defence in Brno, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic

2. Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence in Brno, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic

3. Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic

4. Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03 Hradec Kralove, Czech Republic

5. Transfusion Department, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove – Novy Hradec Kralove, Czech Republic

6. Department of Epidemiology, Military Faculty of Medicine, University of Defence in Brno, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic

Abstract

The increasing threat of nuclear incidents and the widespread use of ionizing radiation (IR) in medical treatments underscore the urgent need for effective radiation countermeasures.

Funder

Ministerstvo Školství, Mládeže a Tělovýchovy

Ministerstvo Obrany České Republiky

Ministerstvo Zdravotnictví Ceské Republiky

Publisher

Royal Society of Chemistry (RSC)

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