Exploring the versatility of pentafulvene–maleimide cycloaddition as a ligation strategy: buffer and pH effects-Reference-Cited by-同舟云学术

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Exploring the versatility of pentafulvene–maleimide cycloaddition as a ligation strategy: buffer and pH effects

Published:2022 Issue:43 Volume:20 Page:8538-8544
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Platts Kirsten¹,Hota Manisha¹^ORCID,Blencowe Chris²,Blencowe Anton¹^ORCID

Affiliation:

1. Applied Chemistry and Translational Biomaterials Group, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia

2. Fleet Bioprocessing, Hartley Whitney, Hampshire, RG27 8DH, UK

Abstract

Pentafulvene–maleimide cycloadditions proceed efficiently in a range of biological buffers of varying pH, highlighting the potential of this strategy as an efficient ligation strategy for the preparation of conjugates.

Funder

Australian Academy of Technology and Engineering

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01453J

Reference41 articles.

1. Chemistry in living systems

2. Development of Bioorthogonal Reactions and Their Applications in Bioconjugation

3. Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation

4. The growing applications of click chemistry

5. Evidence-based guidelines for controlling pH in mammalian live-cell culture systems

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