Synthesis and structure–activity relationship of berkeleylactone A-derived antibiotics-Reference-Cited by-同舟云学术

Synthesis and structure–activity relationship of berkeleylactone A-derived antibiotics

Published:2022 Issue:39 Volume:20 Page:7821-7832
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Malatinský Tomáš¹,Valachová Dominika¹,Pinčeková Lucia¹,Scherhaufer David¹,Olejníková Petra²,Májeková Magdaléna³,Vargová Jarmila⁴,Gaálová-Radochová Barbora⁴,Bujdáková Helena⁴,Nováčiková Jana⁵,Farley Alistair J. M.⁶,Berkeš Dušan¹^ORCID,Jakubec Pavol¹,Kolarovič Andrej⁷^ORCID,Caletková Oľga¹^ORCID

Affiliation:

1. Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia

2. Institute of Biochemistry and Microbiology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia

3. Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine SAS, Dúbravská cesta 9, 841 04 Bratislava, Slovakia

4. Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia

5. Central Laboratories, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia

6. The Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK

7. Department of Chemistry, Faculty of Education, Trnava University, Priemyselná 4, 918 43 Trnava, Slovakia

Abstract

A series of berkeleylactone A derivatives was prepared and evaluated for in vitro antimicrobial activities. Our data confirmed the essential role of the embedded Michael acceptor and suggested its reversible sulfa-protection.

Funder

Agentúra na Podporu Výskumu a Vývoja

Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01452A

Reference33 articles.

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