A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8-Reference-Cited by-同舟云学术

A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8

Published:2019 Issue:98 Volume:55 Page:14777-14780
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Nardelli Francesca¹²³^ORCID,Ghitti Michela¹²³^ORCID,Quilici Giacomo¹²³^ORCID,Gori Alessandro⁴⁵⁶³^ORCID,Luo Qingqiong⁷⁸⁹¹⁰^ORCID,Berardi Andrea¹²³^ORCID,Sacchi Angelina¹²³^ORCID,Monieri Matteo¹²³^ORCID,Bergamaschi Greta⁴⁵⁶³^ORCID,Bermel Wolfgang¹¹¹²¹³,Chen Fuxiang⁷⁸⁹¹⁰^ORCID,Corti Angelo¹²³¹⁴²^ORCID,Curnis Flavio¹²³^ORCID,Musco Giovanna¹²³^ORCID

Affiliation:

1. IRCCS San Raffaele Scientific Institute

2. 20132 Milan

3. Italy

4. Istituto di Chimica del Riconoscimento Molecolare

5. C.N.R.

6. 20131 Milan

7. Ninth People's Hospital

8. Shanghai Jiao Tong University School of Medicine

9. Shanghai

10. China

11. Bruker BioSpin GmbH

12. Rheinstetten

13. Germany

14. Vita Salute San Raffaele University

Abstract

Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations.

Funder

Horizon 2020

Associazione Italiana per la Ricerca sul Cancro

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC08518A

Reference31 articles.

1. αv integrins: key regulators of tissue fibrosis

2. Integrin αvβ6: Structure, function and role in health and disease

3. Exploring the Role of RGD-Recognizing Integrins in Cancer

4. Integrin Structure, Activation, and Interactions

5. Molecular Basis of the Ligand Binding Specificity of αvβ8 Integrin

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A simple and robust nanosystem for photoacoustic imaging of bladder cancer based on α5β1-targeted gold nanorods;Journal of Nanobiotechnology;2023-08-27

2. A stapled chromogranin A-derived peptide homes in on tumors that express αvβ6 or αvβ8 integrins;International Journal of Biological Sciences;2023

3. Early diagnosis of bladder cancer by photoacoustic imaging of tumor-targeted gold nanorods;Photoacoustics;2022-12

4. Neuropilin-1 and Integrins as Receptors for Chromogranin A-Derived Peptides;Pharmaceutics;2022-11-22

5. Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand;Journal of Medicinal Chemistry;2021-05-07