Generation of cycloheptynes and cyclooctynes via a sulfoxide–magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates

Author:

Yoshida Suguru12345,Karaki Fumika12345,Uchida Keisuke12345,Hosoya Takamitsu12345

Affiliation:

1. Laboratory of Chemical Bioscience

2. Institute of Biomaterials and Bioengineering

3. Tokyo Medical and Dental University

4. Tokyo 101-0062

5. Japan

Abstract

Cycloheptynes and cyclooctynes have been efficiently generated via a sulfoxide–magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Reference55 articles.

1. R. W. Hoffmann , Dehydrobenzene and Cycloalkynes, Academic Press, New York, 1967

2. Angle strained cycloalkynes

3. H. Hopf and J.Grunenberg, in Strained Hydrocarbons, ed. H. Dodziuk, Wiley-VCH, Weinheim, 2009, ch. 7

4. A Strain-Promoted [3 + 2] Azide−Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems

5. Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry

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