Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas-Reference-Cited by-同舟云学术

Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas

Published:2020 Issue:15 Volume:49 Page:4732-4740
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Clough Thomas J.¹²³⁴⁵,Baxan Nicoleta⁶⁷⁸⁴⁵^ORCID,Coakley Emma J.¹²³⁴⁵,Rivas Charlotte¹²³⁴⁵^ORCID,Zhao Lan⁶⁷⁸⁴⁵,Leclerc Isabelle⁹¹⁰¹¹⁷⁸,Martinez-Sanchez Aida⁹¹⁰¹¹⁷⁸,Rutter Guy A.⁹¹⁰¹¹⁷⁸^ORCID,Long Nicholas J.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Molecular Sciences Research Hub

3. Imperial College London

4. London

5. UK

6. Biological Imaging Centre

7. Faculty of Medicine

8. Hammersmith Hospital

9. Section of Cell Biology and Functional Genomics

10. Department of Metabolism

11. Digestion and Reproduction

Abstract

A novel probe based on an exendin-4-dota(ga) conjugate, GdEx, is presented. GdEx accumulates in the pancreas, allowing organ-specific contrast enhancement which is reduced in mouse models where pancreatic β-cells are depleted.

Funder

Wellcome Trust

Medical Research Council

Diabetes UK

Horizon 2020

Engineering and Physical Sciences Research Council

Royal Society

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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