Azabicyclic vinyl sulfones for residue-specific dual protein labelling-Reference-Cited by-同舟云学术

Azabicyclic vinyl sulfones for residue-specific dual protein labelling

Published:2019 Issue:16 Volume:10 Page:4515-4522
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Gil de Montes Enrique¹²³⁴⁵,Jiménez-Moreno Ester⁶⁷⁸⁹^ORCID,Oliveira Bruno L.⁶⁷⁸⁹¹⁰,Navo Claudio D.¹¹¹²¹³¹⁴⁵,Cal Pedro M. S. D.¹⁰¹⁵¹⁶¹⁷,Jiménez-Osés Gonzalo¹¹¹²¹³¹⁴⁵^ORCID,Robina Inmaculada¹²³⁴⁵^ORCID,Moreno-Vargas Antonio J.¹²³⁴⁵^ORCID,Bernardes Gonçalo J. L.⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Departamento de Química Orgánica

2. Facultad de Química

3. Universidad de Sevilla

4. 41012-Sevilla

5. Spain

6. Department of Chemistry

7. University of Cambridge

8. CB2 1EW Cambridge

9. UK

10. Instituto de Medicina Molecular

11. Departamento de Química

12. Centro de Investigación en Síntesis Química

13. Universidad de La Rioja

14. 26006 Logroño

15. Faculdade de Medicina da Universidade de Lisboa

16. 1649-028 Lisboa

17. Portugal

Abstract

We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation.

Funder

Engineering and Physical Sciences Research Council

Fundação para a Ciência e a Tecnologia

Universidad de Sevilla

H2020 Marie Skłodowska-Curie Actions

H2020 European Research Council

Ministerio de Ciencia e Innovación

Royal Society

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry