C-Terminally modified peptides via cleavage of the HMBA linker by O-, N- or S-nucleophiles-Reference-Cited by-同舟云学术

C-Terminally modified peptides via cleavage of the HMBA linker by O-, N- or S-nucleophiles

Published:2016 Issue:12 Volume:14 Page:3238-3245
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hansen J.¹²³⁴,Diness F.¹²³⁴,Meldal M.¹²³⁴

Affiliation:

1. Center for Evolutionary Chemical Biology

2. Department of Chemistry University of Copenhagen

3. 2100 Copenhagen

4. Denmark

Abstract

A direct and convenient method for the release of protected peptides with C-terminal modification from the HMBA linker by nucleophilic cleavage with amines, alcoholates or thiolates.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00213G

Reference29 articles.

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4. A convenient approach to synthesizing peptide C-terminal N-alkyl amides

5. Synthesis and Evaluation of Iron Chelators with Masked Hydrophilic Moieties

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