Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients-Reference-Cited by-同舟云学术

Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients

Published:2019 Issue:6 Volume:17 Page:1552-1557
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Aguiar Renata M.¹²³⁴⁵^ORCID,Leão Raquel A. C.¹²³⁴⁵^ORCID,Mata Alejandro⁶⁷⁸⁹¹⁰^ORCID,Cantillo David⁶⁷⁸⁹¹⁰^ORCID,Kappe C. Oliver⁶⁷⁸⁹¹⁰^ORCID,Miranda Leandro S. M.¹²³⁴⁵^ORCID,de Souza Rodrigo O. M. A.¹²³⁴⁵^ORCID

Affiliation:

1. Biocatalysis and Organic Synthesis Group

2. ChemistryInstitute

3. Federal Universityof Rio de Janeiro

4. Rio de Janeiro

5. Brazil

6. Center for Continuous Flow Synthesis and Processing (CCFLOW)

7. Research Center Pharmaceutical Engineering GmbH (RCPE)

8. Graz

9. Austria

10. Institute of Chemistry

Abstract

Continuous-flow production of chiral intermediates plays an important role in the development of building blocks for Active Pharmaceutical Ingredients (APIs), being α-amino acids and their derivatives widely applied as building blocks.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB03088J

Reference33 articles.

1. Scaleable catalytic asymmetric Strecker syntheses of unnatural α-amino acids