QM/MM study of the mechanism of reduction of 3-hydroxy-3-methylglutaryl coenzyme A catalyzed by human HMG-CoA reductase
Author:
Affiliation:
1. REQUIMTE
2. Departamento de Química e Bioquímica
3. Faculdade de Ciências
4. Universidade do Porto
5. 4169-007 Porto
Abstract
Detailing with atomistic resolution the reaction mechanism of human HMG-CoA reductase (HMG-CoA-R) might provide valuable insights for the development of new cholesterol-lowering drugs.
Funder
Fundação para a Ciência e a Tecnologia
Publisher
Royal Society of Chemistry (RSC)
Subject
Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2016/CY/C6CY00356G
Reference58 articles.
1. Sterols and Isoprenoids: Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway
2. Isoprenoid biosynthesis: The evolution of two ancient and distinct pathways across genomes
3. Sequence Comparisons Reveal Two Classes of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase
4. Bacterial and mammalian HMG-CoA reductases: related enzymes with distinct architectures
5. The structure of the catalytic portion of human HMG-CoA reductase
Cited by 20 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Gold electrode modified with proteoliposome-derived bilayer for electrochemical studies of HMG‑CoA reductase and its inhibition;Electrochimica Acta;2024-02
2. Computational Study of Base-Catalyzed Thiohemiacetal Decomposition in Pseudomonas mevalonii HMG-CoA Reductase;The Journal of Physical Chemistry B;2023-05-23
3. Gold Electrode Modified with Proteoliposome-Derived Bilayer for Electrochemical Studies of Hmg‑Coa Reductase and its Inhibition;2023
4. A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action;Nature Communications;2022-09-22
5. A resistance-gene-directed tolerance trait and selective inhibitors proffer HMG-CoA reductase as a new herbicide mode of action;2022-04-19
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3