PARP-1 inhibitor alleviates liver lipid accumulation of atherosclerosis <i>via</i> modulating bile acid metabolism and gut microbes-Reference-Cited by-同舟云学术

PARP-1 inhibitor alleviates liver lipid accumulation of atherosclerosis via modulating bile acid metabolism and gut microbes

Published:2023 Issue:7 Volume:19 Page:560-573
ISSN:2515-4184
Container-title:Molecular Omics
language:en
Short-container-title:Mol. Omics

Author:

Sheng Yingkun¹,Meng Guibing¹,Zhou Zhirong¹^ORCID,Du Ruijiao²^ORCID,Wang Yuefei¹³,Jiang Miaomiao¹³^ORCID

Affiliation:

1. State Key Laboratory of Component-based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China

2. Department of Pharmacy, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China

3. Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China

Abstract

Inhibitor of poly(ADP-ribose) polymerase 1,3-AB, improves liver lipid accumulation in atherosclerosis by increasing liver FXR/BSEP and decreasing ileal FXR/FGF15 levels, modulating bile acid metabolism and bile salt hydrolase-related gut microbes, especially Bifidobacterium.

Funder

Tianjin Science and Technology Program

Tianjin Research Innovation Project for Postgraduate Students

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MO/D3MO00033H

Reference44 articles.

1. Atherosclerosis

2. Guanmaitong Granule Attenuates Atherosclerosis by Inhibiting Inflammatory Immune Response in ApoE−/− Mice Fed High-Fat Diet

3. Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

4. Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

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