Dextran-coated superparamagnetic nanoparticles as potential cancer drug carriers in vivo

Author:

Peng Mingli12345,Li Houli5634,Luo Zhiyi5634,Kong Jian7891011,Wan Yinsheng121314,Zheng Lemin7891011,Zhang Qinlu5634,Niu Hongxin151617,Vermorken Alphons5634,Van de Ven Wim18192021,Chen Chao5634,Zhang Xikun151617,Li Fuqiang5634,Guo Lili5634,Cui Yali5634

Affiliation:

1. Key Laboratory of Synthetic and Natural Functional Molecular Chemistry of Ministry of Education

2. College of Chemistry and Materials Science

3. Northwest University

4. Xi'an, P. R. China

5. National Engineering Research Center for Miniaturized Detection Systems

6. College of Life Sciences

7. The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine

8. School of Basic Medical Sciences

9. and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education

10. Peking University Health Science Center

11. Beijing, P. R. China

12. Department of Biology

13. Providence College

14. Providence, USA

15. Department of Minimally Invasive Surgery

16. Affiliated Hospital of Shandong Academy of Medical Science

17. Jinan, P. R. China

18. Laboratory for Molecular Oncology

19. Department of Human Genetics

20. University of Leuven

21. Belgium

Abstract

Dextran-coated SPIONs (DSPIONs) are synthesized and used as drug magnetic carriers to form conjugates of Dox–DSPIONs. The cytotoxicity, intracellular uptake behavior and anti-tumor activity of the conjugates are investigated.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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