C(3)-Aryl isoindolinones: a PTSA-mediated access and improved synthesis of (±)-nuevamine-Reference-Cited by-同舟云学术

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C(3)-Aryl isoindolinones: a PTSA-mediated access and improved synthesis of (±)-nuevamine

Published:2023 Issue:41 Volume:47 Page:19283-19288
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Rao H. Surya Prakash¹²^ORCID,J Prabhakaran¹

Affiliation:

1. Department of Chemistry, Pondicherry University, Puducherry-605 014, India

2. Teadus Pharma Private Limited, Prashanth Nagar, Hyderabad, Telangana 500 072, India

Abstract

We achieved a facile synthesis of some C(3)-aryl isoindolinones with free N(2)H from isoindolinone-3-ols and electron-rich aromatic compounds in a two-step method. In continuation we demonstrated a high yielding synthesis of the tetracyclic alkaloid nuevamine.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ03498D

Reference66 articles.

1. Discovery of Isoindoline Amide Derivatives as Potent and Orally Bioavailable ADAMTS-4/5 Inhibitors for the Treatment of Osteoarthritis

2. Design, Synthesis, and Evaluation of Isoindoline Derivatives as New Antidepressant Agents

3. Photoinduced Synthesis of Methylated Marine Cyclopeptide Galaxamide Analogs with Isoindolinone as Anticancer Agents

4. The chemistry of isoindole natural products

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