Injectable hydrogels for bone regeneration with tunable degradability via peptide chirality modification

Author:

Chen Weikai12345,Sheng Shihao6,Tan Kai45,Wang Sicheng1237,Wu Xiang123,Yang Jiayi8,Hu Yan6,Cao Liehu9,Xu Ke123,Zhou Fengjin10,Su Jiacan1236ORCID,Zhang Qin123ORCID,Yang Lei45ORCID

Affiliation:

1. Institute of Translational Medicine, Shanghai University, Shanghai 200444, P. R. China

2. Organoid Research Center, Shanghai University, Shanghai 200444, P. R. China

3. National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai 200444, P. R. China

4. Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325003, P. R. China

5. Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang 325035, P. R. China

6. Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P. R. China

7. Department of Orthopedics, Shanghai Zhongye Hospital, Shanghai 200941, P. R. China

8. Department of Gynaecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325003, P. R. China

9. Department of Orthopedics, Shanghai Luodian Hospital, Shanghai 201908, P. R. China

10. Honghui Hospital, Xi'an Jiao Tong University, Xi'an 710000, P. R. China

Abstract

A matrix metalloproteinase (MMP)-responsive degradable hydrogel crosslinked with l-chiral MMP-sensitive peptides exhibits an enhanced degradation rate, contributing to promoted cell migration for effective bone regeneration.

Funder

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Natural Science Foundation of Shanghai Municipality

Science and Technology Plan Project of Wenzhou Municipality

Publisher

Royal Society of Chemistry (RSC)

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