Development of a gliclazide ionic liquid and its mesoporous silica particles: an effective formulation strategy to improve oral absorption properties-Reference-Cited by-同舟云学术

Development of a gliclazide ionic liquid and its mesoporous silica particles: an effective formulation strategy to improve oral absorption properties

Published:2022 Issue:2 Volume:12 Page:1062-1076
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhou Bijian¹,Teng Dan²,Li Jinghui¹,Zhang Yanhong¹,Qi Minghui¹^ORCID,Hong Minghuang¹^ORCID,Ren Guo-Bin¹³^ORCID

Affiliation:

1. Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Laboratory of Pharmaceutical Crystal Engineering & Technology, East China University of Science and Technology, No. 130 Meilong Road, Shanghai 200237, China

2. Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

3. State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, No. 130 Meilong Road, Shanghai 200237, China

Abstract

An ionic liquid (IL) form of gliclazide with enhanced solubility characteristics was successfully synthesized. This IL could be loaded into mesoporous silica carrier and exhibited improved dissolution behavior in vitro.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shanghai

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D1RA07499G

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1. Subtypes of Type 2 Diabetes Determined From Clinical Parameters

2. Epidemiological studies of the association between reproductive lifespan characteristics and risk of Type 2 diabetes and hypertension: A systematic review