Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition-Reference-Cited by-同舟云学术

Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition

Published:2020 Issue:5 Volume:18 Page:931-940
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Goyard David¹²³⁴⁵^ORCID,Kónya Bálint⁶⁷⁸⁹,Czifrák Katalin⁶⁷⁸⁹,Larini Paolo¹²³⁴⁵^ORCID,Demontrond Fanny¹²³⁴⁵,Leroy Jérémy¹⁰¹¹¹²¹³⁵,Balzarin Sophie¹⁰¹¹¹²¹³⁵,Tournier Michel¹⁰¹¹¹²¹³⁵,Tousch Didier¹⁰¹¹¹²¹³⁵,Petit Pierre¹⁰¹¹¹²¹³⁵,Duret Cédric¹⁴¹³⁵¹⁰¹⁵,Maurel Patrick¹⁴¹³⁵¹⁰¹⁵,Docsa Tibor¹⁶⁷¹⁷⁹,Gergely Pál¹⁶⁷¹⁷⁹,Somsák László⁶⁷⁸⁹^ORCID,Praly Jean-Pierre¹²³⁴⁵,Azay-Milhau Jacqueline¹⁰¹¹¹²¹³⁵,Vidal Sébastien¹²³⁴⁵^ORCID

Affiliation:

1. Institut de Chimie et Biochimie Moléculaires et Supramoléculaires

2. UMR 5246

3. CNRS

4. F-69622 Villeurbanne

5. France

6. Department of Organic Chemistry

7. University of Debrecen

8. H-4002 Debrecen

9. Hungary

10. Montpellier University

11. EA7288

12. Biocommunication in cardiometabolism (BC2M)

13. Montpellier

14. INSERM U1040

15. UMR-1040

16. Institute of Medical Chemistry

17. H-4012 Debrecen

Abstract

Spiro-glyco-heterocycles were prepared on a gram scale from a thiolactone obtained by thermolysis of a thiosulfinate. Lowering of glycaemia in diabetic rat models is pointing toward potential new treatment of type 2 diabetes.

Funder

Centre National de la Recherche Scientifique

Magyar Tudományos Akadémia

Agence Nationale de la Recherche

Université Claude Bernard Lyon 1

European Regional Development Fund

Országos Tudományos Kutatási Alapprogramok

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB01190K

Reference74 articles.

1. Advances in the Treatment of Type 2 Diabetes Mellitus

2. Current anti-diabetic agents and their molecular targets: A review

3. Inhibition of glycogenolysis in primary rat hepatocytes by 1,4-dideoxy-1,4-imino-D-arabinitol

4. Prospects for Pharmacologic Inhibition of Hepatic Glucose Production

5. B. R. Henke , Inhibition of glycogen phosphorylase as a strategy for the treatment of type 2 diabetes mellitus , in New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches , ed. R. M. Jones , RSC Drug Discovery, Dorset Press , Dorchester, UK , 2012 , ch. 12, pp. 324–365

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