Synthesis of easily-modified and useful dibenzo-[<i>b,d</i>]azepines by palladium(<scp>ii</scp>)-catalyzed cyclization/addition with a green solvent-Reference-Cited by-同舟云学术

Synthesis of easily-modified and useful dibenzo-[b,d]azepines by palladium(ii)-catalyzed cyclization/addition with a green solvent

Published:2024 Issue:26 Volume:60 Page:3587-3590
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Cheng Hua¹²³^ORCID,Liu Rongqi¹,Fang Shengyang¹,Li Zixiang¹,Zhang Denggao¹,Zhang Xi³^ORCID,Chen Wenfei⁴,Chen Huixin⁴,Kang Leyi³,Wang Juan⁴^ORCID,Xu Yulong³^ORCID,Song Shaoli²^ORCID,Shao Liming¹^ORCID

Affiliation:

1. School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai, 201203, China

2. China Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, No. 270, Dong'an Road, Xuhui District, Shanghai 200032, China

3. Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA

4. School of Medicine, Shanghai University, Shanghai 200444, China

Abstract

An eco-friendly method based on palladium-catalyzed tandem cyclization has been developed to synthesize novel dibenzo[b,d]azepines. Then substrates were expanded and a medicinal chemistry project was designed upon with dibenzo[b,d]azepines.

Funder

Program of Shanghai Academic Research Leader

National Natural Science Foundation of China

Key Programme

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D3CC06321F

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