Synthesis of easily-modified and useful dibenzo-[b,d]azepines by palladium(ii)-catalyzed cyclization/addition with a green solvent

Author:

Cheng Hua123ORCID,Liu Rongqi1,Fang Shengyang1,Li Zixiang1,Zhang Denggao1,Zhang Xi3ORCID,Chen Wenfei4,Chen Huixin4,Kang Leyi3,Wang Juan4ORCID,Xu Yulong3ORCID,Song Shaoli2ORCID,Shao Liming1ORCID

Affiliation:

1. School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai, 201203, China

2. China Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, No. 270, Dong'an Road, Xuhui District, Shanghai 200032, China

3. Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA

4. School of Medicine, Shanghai University, Shanghai 200444, China

Abstract

An eco-friendly method based on palladium-catalyzed tandem cyclization has been developed to synthesize novel dibenzo[b,d]azepines. Then substrates were expanded and a medicinal chemistry project was designed upon with dibenzo[b,d]azepines.

Funder

Program of Shanghai Academic Research Leader

National Natural Science Foundation of China

Key Programme

Publisher

Royal Society of Chemistry (RSC)

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