Identification of novel aptamers targeting cathepsin B-overexpressing prostate cancer cells-Reference-Cited by-同舟云学术

Identification of novel aptamers targeting cathepsin B-overexpressing prostate cancer cells

Published:2022 Issue:6 Volume:7 Page:637-650
ISSN:2058-9689
Container-title:Molecular Systems Design & Engineering
language:en
Short-container-title:Mol. Syst. Des. Eng.

Author:

Pereira Ana Cláudia¹²³,Pina André F.⁴⁵^ORCID,Sousa Diana¹²,Ferreira Débora¹²,Santos-Pereira Cátia¹²,Rodrigues Joana L.¹²^ORCID,Melo Luís D. R.¹²,Sales Goreti³^ORCID,Sousa Sérgio F.⁴⁵^ORCID,Rodrigues Lígia R.¹²^ORCID

Affiliation:

1. CEB – Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal

2. LABBELS – Associate Laboratory, Guimarães, Braga, Portugal

3. Biomark, Sensor Research, Superior Institute of Engineering of Porto, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal

4. Associate Laboratory i4HB – Institute for Health and Bioeconomy, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal

5. UCIBIO – Applied Molecular Biosciences Unit, BioSIM – Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal

Abstract

For the first time, an aptamer that specifically binds to cathepsin B (CatB)-overexpressing prostate cancer cells was identified by combining SELEX and computational tools.

Funder

Fundação para a Ciência e a Tecnologia

European Social Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomedical Engineering,Chemical Engineering (miscellaneous),Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/ME/D2ME00022A

Reference61 articles.

1. Cathepsin B as a cancer target

2. Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion

3. Cathepsin B expression in colorectal cancer in a Middle East population: Potential value as a tumor biomarker for late disease stages

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