18α-Glycyrrhetinic acid monoglucuronide as an anti-inflammatory agent through suppression of the NF-κB and MAPK signaling pathway

Author:

Li Bo1234,Yang Yongan564,Chen Liuzeng1234,Chen Shichao1234,Zhang Jing784,Tang Wenjian1234ORCID

Affiliation:

1. School of Pharmacy

2. Anhui Medical University

3. Hefei 230032

4. China

5. Elion Nature Biological Technology Co., Ltd

6. Nanjing 210038

7. Anhui Prevention and Treatment Center for Occupational Disease

8. Hefei 230022

Abstract

18α-GAMG exhibited strong anti-inflammatory activity through inhibiting the expression of iNOS, COX-2, and MAPKs, as well as activation of NF-κB.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

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