Tumor-targeting intracellular drug delivery based on dual acid/reduction-degradable nanoassemblies with ketal interface and disulfide core locations
Author:
Affiliation:
1. Department of Chemistry and Biochemistry
2. Concordia University
3. Montreal
4. Canada H4B 1R6
5. Institute of Medicinal Plant Development (IMPLAD)
6. Chinese Academy of Medical Sciences & Peking Union Medical College
7. Beijing 100193
8. China
Abstract
Dual acid/reduction-degradable block copolymer nanoassemblies both at core/corona interfaces and in micellar cores leading to synergistic and accelerated drug release for robust tumor-targeting intracellular drug delivery.
Funder
Canada Research Chairs
Mitacs
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering
Link
http://pubs.rsc.org/en/content/articlepdf/2019/PY/C9PY00352E
Reference53 articles.
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5. Nano-engineering block copolymer aggregates for drug delivery
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