Mechanical unfolding of alpha- and beta-helical protein motifs
Author:
Affiliation:
1. Department of Civil and Environmental Engineering and Mechanical Engineering
2. Northwestern University
3. Evanston
4. USA
Abstract
Alpha-helices and beta-sheets are the two most common secondary motifs in proteins. Beta-helices combine features of both motifs to perform a wide variety of functions. Possessing a larger width to height ratio, beta-helices resist unfolding by rotating to larger angles with respect to the loading direction, resulting in hydrogen bonds being ruptured in shear or out of plane peeling rather than in-plane peeling. This allows beta-helices to achieve greater energy dissipation per residue than alpha-helices.
Funder
Office of Naval Research
Air Force Office of Scientific Research
Publisher
Royal Society of Chemistry (RSC)
Subject
Condensed Matter Physics,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/SM/C8SM02046A
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