In silico studies of ASEM analogues targeting α7-nAChR and experimental verification-Reference-Cited by-同舟云学术

In silico studies of ASEM analogues targeting α7-nAChR and experimental verification

Published:2021 Issue:7 Volume:11 Page:3942-3951
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhou Yang¹²³⁴⁵,Kuang Guanglin⁶⁷⁸⁹¹⁰,Li Junhao⁶⁷⁸⁹¹⁰,Halldin Christer¹¹¹²¹³¹⁰¹⁴,Nordberg Agneta¹⁵¹⁶¹⁷¹⁸¹⁹^ORCID,Långström Bengt²⁰²¹²²¹⁴,Tu Yaoquan⁶⁷⁸⁹¹⁰^ORCID,Ågren Hans⁵²¹²³¹⁴²⁴^ORCID

Affiliation:

1. School of Pharmacy

2. Jinan University

3. Guangzhou

4. China

5. Department of Physics and Astronomy

6. Division of Theoretical Chemistry and Biology

7. School of Biotechnology

8. Royal Institute of Technology (KTH)

9. AlbaNova University Center

10. Stockholm

11. Karolinska Institutet

12. Department of Clinical Neuroscience

13. Centre for Psychiatric Research

14. Sweden

15. Nordberg Translational Molecular Imaging Lab

16. Division of Clinical Geriatrics

17. Center for Alzheimer Research

18. Department of Neurobiology

19. Care Sciences and Society

20. Department of Chemistry

21. Uppsala University

22. Uppsala

23. SE-751 20 Uppsala

24. College of Chemistry and Chemical Engineering

Abstract

The in silico binding free energies of the ASEM analogues targeting α7-nAChR are in line with the inhibition obtained from in vitro binding assays.

Funder

Stiftelsen för Strategisk Forskning

Ministry of Science and Higher Education of the Russian Federation

Henan University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA10435C

Reference29 articles.

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5. Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia

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