Development of thiazole-appended novel hydrazones as a new class of α-amylase inhibitors with anticancer assets: an <i>in silico</i> and <i>in vitro</i> approach-Reference-Cited by-同舟云学术

Development of thiazole-appended novel hydrazones as a new class of α-amylase inhibitors with anticancer assets: an in silico and in vitro approach

Published:2023 Issue:4 Volume:14 Page:757-781
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Chahal Sandhya¹,Punia Jyoti¹,Rani Payal¹^ORCID,Singh Rajvir¹,Mayank ²^ORCID,Kumar Parvin³^ORCID,Kataria Ramesh⁴^ORCID,Joshi Gaurav⁵^ORCID,Sindhu Jayant¹^ORCID

Affiliation:

1. Department of Chemistry, COBS&H, CCS Haryana Agricultural University, Hisar, 125004, India

2. 3IT – Université de Sherbrooke, 3000 Bd de l'Université Immeuble P2, Sherbrooke, QC J1K 0A5, Canada

3. Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, India

4. Department of Chemistry, Panjab University, Chandigarh, 160014, India

5. Department of Pharmaceutical Sciences, Hemvati Nandan Bahuguna Garhwal (A Central) University, Chauras Campus, Tehri Garhwal, 249161 Uttarakhand, India

Abstract

Thiazole-clubbed hydrazones exhibited in vitro α-amylase inhibitory response in the range of IC50 values from 0.23 ± 0.003 to 0.5 ± 0.0 μM. 5b was found to be the least cytotoxic and most potent α-amylase inhibitor.

Funder

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00431C

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