Macrocyclic derivatives of 6-methyluracil as ligands of the peripheral anionic site of acetylcholinesterase-Reference-Cited by-同舟云学术

Macrocyclic derivatives of 6-methyluracil as ligands of the peripheral anionic site of acetylcholinesterase

Published:2014 Issue:11 Volume:5 Page:1729-1735
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Semenov Vyacheslav E.¹²,Giniyatullin Rashit Kh.¹²,Lushchekina Sofya V.³⁴,Kots Ekaterina D.⁵⁴,Petrov Konstantin A.¹²⁶⁷⁸,Nikitashina Alexandra D.¹²⁶⁷⁸,Minnekhanova Oksana A.¹²,Zobov Vladimir V.¹²⁸⁹,Nikolsky Evgeny E.¹²⁶⁷⁸,Masson Patrick⁸⁹¹⁰¹¹¹²,Reznik Vladimir S.¹²

Affiliation:

1. A. E. Arbuzov Institute of Organic and Physical Chemistry

2. Kazan 420088, Russia

3. N. M. Emanuel Institute of Biochemical Physics

4. Moscow 119991, Russia

5. M. V. Lomonosov Moscow State University

6. Kazan Institute of Biochemistry and Biophysics

7. Kazan 420111, Russia

8. Kazan Federal University

9. Kazan 420000, Russia

10. DYNAMOP

11. Institut de Biologie Structurale

12. Grenoble 38000, France

Abstract

Pyrimidinophanes 2a,b bind AChE in the PAS or in the active centre depending on the nature of the spacer between ammonium moieties. Pyrimidinophane 2b and its acyclic counterpart abolished symptoms of muscle weakness.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00225C

Reference20 articles.

1. Acetylcholinesterase inhibitors and cholinergic modulation in Myasthenia Gravis and neuroinflammation

2. Cholinesterase Inhibitors: A New Class of Psychotropic Compounds

3. Acetylcholinesterase: From 3D structure to function

4. Acetylcholinesterase in cell adhesion, neurite growth and network formation

5. Acetylcholinesterase inhibitors as Alzheimer therapy: From nerve toxins to neuroprotection

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