Triazine-pyridine chemistry for protein labelling on tyrosine-Reference-Cited by-同舟云学术

Triazine-pyridine chemistry for protein labelling on tyrosine

Published:2022 Issue:50 Volume:58 Page:7066-7069
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Jiang Hongfei¹,Zhang Qing²,Zhang Yue²,Feng Huxin¹,Jiang Hao¹,Pu Fan²,Yu Rilei¹^ORCID,Zhong Zheng²^ORCID,Wang Chaoming¹,Fung Yi Man Eva²^ORCID,Blasco Pilar²,Li Yongxin²,Jiang Tao¹^ORCID,Li Xuechen²^ORCID

Affiliation:

1. Key Laboratory of Marine Drugs Chinese Ministry of Education, Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China

2. Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China

Abstract

Herein, we discover the new reactivity of the 1,3,5-triazine moiety reacting with a phenol group and report the development of biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine labelling under physiological conditions and profiling in the whole proteome.

Funder

National Natural Science Foundation of China

Research Grants Council, University Grants Committee

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC01528E

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