Inactivation of myostatin by photooxygenation using functionalized <scp>d</scp>-peptides-Reference-Cited by-同舟云学术

Inactivation of myostatin by photooxygenation using functionalized d-peptides

Published:2023 Issue:2 Volume:14 Page:386-392
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Okamoto Hideyuki¹,Murano Shuko Amber¹,Ikekawa Kaoru¹,Katsuyama Masahiro¹,Konno Sho¹,Taguchi Akihiro¹,Takayama Kentaro¹²,Taniguchi Atsuhiko¹^ORCID,Hayashi Yoshio¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan

2. Department of Environmental Biochemistry, Kyoto Pharmaceutical University, 5 Misasaginakauchi-cho, Yamashina, Kyoto 607-8414, Japan

Abstract

Myostatin-binding d-peptides functionalized with photocatalyst efficiently inactivate myostatin by photooxygenation and show no phototoxicity and high resistance to proteolytic enzymes, leading to the treatment of muscular atrophic diseases.

Funder

Japan Society for the Promotion of Science

Takeda Science Foundation

Uehara Memorial Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00425A

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