Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella-Reference-Cited by-同舟云学术

Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella

Published:2022 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Guan Xiang-Na¹²^ORCID,Zhang Tao¹^ORCID,Yang Teng¹³,Dong Ze¹,Yang Song³^ORCID,Lan Lefu¹²⁴,Gan Jianhua⁵,Yang Cai-Guang¹²⁴^ORCID

Affiliation:

1. Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

2. University of the Chinese Academy of Sciences, Beijing 100049, China

3. State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang 550025, China

4. School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China

5. School of Life Sciences, Fudan University, Shanghai 200433, China

Abstract

Covalent sortase A inhibitor ML346 prevents Galleria mellonella from Staphylococcus aureus infection by interfering in the transpeptidation activity of sortase A for anchoring surface proteins into staphylococci envelope.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D1MD00316J

Reference64 articles.

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4. World Health Organization , 2020 Antibacterial agents in clinical and preclinical development: an overview and analysis , Report 978–92–4-002130-3, 2021

5. Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

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