Continuous flow asymmetric synthesis of chiral active pharmaceutical ingredients and their advanced intermediates-Reference-Cited by-同舟云学术

Continuous flow asymmetric synthesis of chiral active pharmaceutical ingredients and their advanced intermediates

Published:2021 Issue:17 Volume:23 Page:6117-6138
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Ötvös Sándor B.¹²^ORCID,Kappe C. Oliver¹²^ORCID

Affiliation:

1. Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria

2. Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, A-8010 Graz, Austria

Abstract

This review surveys continuous flow approaches for the synthesis of chiral APIs and their advanced stereogenic intermediates, covering the utilization of biocatalysis, organometallic catalysis and metal-free organocatalysis to introduce asymmetry.

Funder

Austrian Science Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/GC/D1GC01615F

Reference219 articles.

1. Stereoselective Synthesis of Drugs and Natural Products , ed. V. Andrushko and N. Andrushko , John Wiley & Sons , Karlsruhe , 2013

2. Innovative Drug Synthesis , ed. J. J. Li and D. S. Johnson , John Wiley & Sons , Hoboken, New Jersey , 2015

3. R.Vardanyan and V.Hruby , Synthesis of Best-Seller Drugs , Academic Press , London , 2016

4. A. J.Burke , C. S.Marques , N. J.Turner and G. J.Hermann , Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development , John Wiley & Sons , Weinheim , 2018

5. Chiral Drugs: Chemistry and Biological Action , ed. G. Lin , Q. You and J. Cheng , John Wiley & Sons , Hoboken, New Jersey , 2011

Cited by 60 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Amberlyst-A26-Mediated Corey–Chaykovsky Cyclopropanation of 9-Alkylidene-9H-fluorene under Continuous Process;The Journal of Organic Chemistry;2024-02-05

2. Development of heterogeneous enzymatic cascades with a case study for a separable and recyclable system using a combination of magnetic and nonmagnetic supports;Journal of Chemical Technology & Biotechnology;2024-01-31

3. Enantioselective Flow Synthesis of a Tetrahydroquinoline SERM Enabled by Immobilized Chiral Phosphoric Acid Catalysis and Diboronic Acid Mediated Selective Nitro Reduction;Advanced Synthesis & Catalysis;2024-01-26

4. A Silica‐Supported Yttrium Triflate Packed Bed Reactor for Continuous Flow Michael Addition of Indoles to Benzylidene Malonates;Advanced Synthesis & Catalysis;2024-01-26

5. Continuous-Flow Enantioselective Hydrogenative Enyne Cyclization with Chiral Heterogeneous Rh Catalysts;ACS Catalysis;2024-01-26