The pKa value of the proximal water molecule trans to a high-valent MnVO porphyrin: towards the control of reactivity by pH-Reference-Cited by-同舟云学术

The pKa value of the proximal water molecule trans to a high-valent MnVO porphyrin: towards the control of reactivity by pH

Published:2017 Issue:36 Volume:46 Page:12088-12094
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Saint-Germes Laurie¹²³⁴⁵,Bar Laure⁶⁷⁸⁴,Dejeu Jérôme⁶⁷⁸⁴^ORCID,Spinelli Nicolas⁶⁷⁸⁴,Defrancq Eric⁶⁷⁸⁴^ORCID,Pratviel Geneviève¹²³⁴⁵^ORCID

Affiliation:

1. CNRS

2. Laboratoire de Chimie de Coordination

3. F-31077 Toulouse cedex4

4. France

5. Université de Toulouse

6. Université Grenoble Alpes

7. Département de Chimie Moléculaire-UMR CNRS 5250

8. 38041 Grenoble Cedex 9

Abstract

In water, the protonation state of the proximal water molecule of a high-valent manganese-oxo porphyrin could be controlled by pH. While in interaction with DNA the porphyrin was able to cleave DNA, only when the proximal water molecule was in the form of a hydroxyl group.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/DT/C7DT01829K

Reference39 articles.

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2. Heme Enzyme Structure and Function

3. Fishing for peroxidase protons

4. Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes

5. Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes

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