A biomimetic human disease model of bacterial keratitis using a cornea-on-a-chip system

Author:

Deng Yudan12,Li Lingjun23ORCID,Xu Jian2,Yao Yili12,Ding Jiangtao12,Wang Lei2,Luo Chunxiong245ORCID,Yang Wei2,Li Lingli126ORCID

Affiliation:

1. School of Ophthalmology & Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China

2. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China

3. Wenzhou Key Laboratory of Biomedical Imaging, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China

4. Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China

5. The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, China

6. Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China

Abstract

This study presents a cornea-on-a-chip model for bacterial keratitis, elucidating antibiotic effectiveness in terms of bacterial eradication, cellular apoptosis reduction, and scar formation mitigation, offering new insights for ocular drug testing.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Wenzhou Institute of Biomaterials and Engineering

Publisher

Royal Society of Chemistry (RSC)

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