Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity-Reference-Cited by-同舟云学术

Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity

Published:2017 Issue:1 Volume:8 Page:395-404
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Smith Nichola A.¹²³⁴,Zhang Pingyu¹²³⁴,Greenough Simon E.¹²³⁴,Horbury Michael D.¹²³⁴,Clarkson Guy J.¹²³⁴,McFeely Daniel⁵²³⁴,Habtemariam Abraha¹²³⁴,Salassa Luca⁶⁷⁸⁹¹⁰,Stavros Vasilios G.¹²³⁴,Dowson Christopher G.⁵²³⁴^ORCID,Sadler Peter J.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Warwick

3. Coventry CV4 7AL

4. UK

5. School of Life Sciences

6. CIC biomaGUNE

7. Paseo de Miramón 182

8. Donostia-San Sebastián

9. Spain

10. Kimika Fakultatea

Abstract

The Ru(ii) complex,cis-[Ru(bpy)₂(INH)₂]²⁺is inactive in the dark but highly active towards mycobacteria on photoactivation with visible light when it releases the antituberculosis drug isoniazid (INH).

Funder

European Research Council

Engineering and Physical Sciences Research Council

Ministerio de Economía y Competitividad

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC03028A

Reference59 articles.