Suspect and non-target screening of ovarian follicular fluid and serum – identification of anthropogenic chemicals and investigation of their association to fertility

Author:

Hallberg Ida1ORCID,Plassmann Merle2ORCID,Olovsson Matts3ORCID,Holte Jan34,Damdimopoulou Pauliina5,Sjunnesson Ylva C. B.1ORCID,Benskin Jonathan P.2ORCID,Persson Sara1ORCID

Affiliation:

1. Division of Reproduction, Department of Clinical Sciences, Swedish University of Agricultural Sciences, The Centre for Reproductive Biology in Uppsala, SE-750 07 Uppsala, Sweden

2. Department of Environmental Science, Stockholm University, SE-106 91 Stockholm, Sweden

3. Department of Womeńs and Childreńs Health, Uppsala University, SE-751 85 Uppsala, Sweden

4. Carl von Linnékliniken, SE-751 83 Uppsala, Sweden

5. Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital, SE-141 86 Stockholm, Sweden

Abstract

This work shows the applicability of non-target screening for prioritizing environmental contaminants in the ovarian follicular fluid, identifying both substances associated to embryo quality and with high calculated hazard to humans.

Funder

Svenska Forskningsrådet Formas

Publisher

Royal Society of Chemistry (RSC)

Subject

Management, Monitoring, Policy and Law,Public Health, Environmental and Occupational Health,Environmental Chemistry,General Medicine

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