Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against Candida albicans

Author:

Ahmad Aijaz12345,Wani Mohmmad Younus678910ORCID,Patel Mrudula1112345,Sobral Abilio J. F. N.1013141516,Duse Adriano G.12345,Aqlan Faisal Mohammed1718192021,Al-Bogami Abdullah Saad1718192021

Affiliation:

1. Department of Clinical Microbiology and Infectious Diseases

2. School of Pathology

3. University of the Witwatersrand

4. Faculty of Health Sciences

5. Johannesburg 2193

6. Texas Therapeutics Institute

7. Brown Foundation Institute of Molecular Medicine

8. The University of Texas Health Science Center at Houston

9. USA

10. Departmento de Quimica

11. Department of Oral Biological Sciences

12. School of Oral Health Sciences

13. FCTUC

14. Universidade de Coimbra

15. Coimbra

16. Portugal

17. Chemistry Department

18. Faculty of Science

19. University of Jeddah

20. Jeddah

21. Kingdom of Saudi Arabia

Abstract

Cyclized bis-chalcone derivatives show synergistic antifungal interactions with fluconazole by ergosterol biosynthesis inhibition evidenced by down regulation of ERG11 gene expression.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3