Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against Candida albicans-Reference-Cited by-同舟云学术

Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against Candida albicans

Published:2017 Issue:12 Volume:8 Page:2195-2207
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Ahmad Aijaz¹²³⁴⁵,Wani Mohmmad Younus⁶⁷⁸⁹¹⁰^ORCID,Patel Mrudula¹¹¹²³⁴⁵,Sobral Abilio J. F. N.¹⁰¹³¹⁴¹⁵¹⁶,Duse Adriano G.¹²³⁴⁵,Aqlan Faisal Mohammed¹⁷¹⁸¹⁹²⁰²¹,Al-Bogami Abdullah Saad¹⁷¹⁸¹⁹²⁰²¹

Affiliation:

1. Department of Clinical Microbiology and Infectious Diseases

2. School of Pathology

3. University of the Witwatersrand

4. Faculty of Health Sciences

5. Johannesburg 2193

6. Texas Therapeutics Institute

7. Brown Foundation Institute of Molecular Medicine

8. The University of Texas Health Science Center at Houston

9. USA

10. Departmento de Quimica

11. Department of Oral Biological Sciences

12. School of Oral Health Sciences

13. FCTUC

14. Universidade de Coimbra

15. Coimbra

16. Portugal

17. Chemistry Department

18. Faculty of Science

19. University of Jeddah

20. Jeddah

21. Kingdom of Saudi Arabia

Abstract

Cyclized bis-chalcone derivatives show synergistic antifungal interactions with fluconazole by ergosterol biosynthesis inhibition evidenced by down regulation of ERG11 gene expression.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00440K

Reference40 articles.

1. Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches

2. Incidence of Bloodstream Infections Due to Candida Species and In Vitro Susceptibilities of Isolates Collected from 1998 to 2000 in a Population-Based Active Surveillance Program

3. Antifungal Resistance and New Strategies to Control Fungal Infections

4. Amphotericin B: spectrum and resistance

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