<i>Mycobacterium tuberculosis</i> CitA activity is modulated by cysteine oxidation and pyruvate binding-Reference-Cited by-同舟云学术

Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding

Published:2023 Issue:5 Volume:14 Page:921-933
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Pathirage Rasangi¹^ORCID,Favrot Lorenza²,Petit Cecile²,Yamsek Melvin²,Singh Sarbjit³,Mallareddy Jayapal Reddy³,Rana Sandeep³^ORCID,Natarajan Amarnath¹³⁴⁵^ORCID,Ronning Donald R.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA

2. Department of Chemistry and Biochemistry, University of Toledo, Toledo, OH 43606, USA

3. Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198, USA

4. Department of Genetics Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA

5. Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA

Abstract

The M. tuberculosis citrate synthase regulatory domain binds pyruvate to affect enzyme activity while cysteine oxidation in the same domain eliminates enzyme activity. This affords regulatory control at the protein level of entry to the TCA cycle.

Funder

National Institute of Allergy and Infectious Diseases

U.S. Department of Energy

Michigan Economic Development Corporation

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00058C

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