Pyridine appended 2-hydrazinylthiazole derivatives: design, synthesis, in vitro and in silico antimycobacterial studies

Author:

Matsa Ramkishore1,Makam Parameshwar23,Sethi Guneswar4,Thottasseri Ahammed Ameen1ORCID,Kizhakkandiyil Aswani Raj1,Ramadas Krishna4,Mariappan Vignesh5,Pillai Agieshkumar Balakrishna5,Kannan Tharanikkarasu1ORCID

Affiliation:

1. Department of Chemistry, Pondicherry University, Kalapet, Puducherry 605 014, India

2. Dr Param Laboratories, Plot No. 478, BN. Reddy Nagar, Cherlapally, Hyderabad, Telangana 500 051, India

3. Division of Research and Innovation, Department of Chemistry, Uttaranchal University, Arcadia Grant, P.O. Chandanwari, Premnagar, Dehradun, Uttarakhand, 248007, India

4. Centre for Bioinformatics, Pondicherry University, Puducherry 605 014, India

5. Central Inter-Disciplinary Research Facility (CIDRF), Sri Balaji Vidyapeeth (Deemed to be University), Puducherry 607 402, India

Abstract

Thirty novel pyridine-appended 2-hydrazinylthiazole derivatives have been synthesized and tested for their antimycobacterial activity against Mictrobactrium tuberculosis, H37Rv strain.

Funder

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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