On the interactions between RNA and titrateable lipid layers: implications for RNA delivery with lipid nanoparticles

Author:

Gilbert Jennifer12ORCID,Ermilova Inna3ORCID,Fornasier Marco1ORCID,Skoda Maximilian4ORCID,Fragneto Giovanna56,Swenson Jan3ORCID,Nylander Tommy1278ORCID

Affiliation:

1. Division of Physical Chemistry, Department of Chemistry, Naturvetarvägen 14, Lund University, 22362 Lund, Sweden

2. NanoLund, Lund University, Professorsgatan 1, 223 63 Lund, Sweden

3. Department of Physics, Chalmers University of Technology, 412 96 Gothenburg, Sweden

4. ISIS Neutron and Muon Source, Rutherford Appleton Laboratory, Harwell, Oxford OX11 0QX, UK

5. Institut Laue-Langevin, 71 avenue des Martyrs, CS 20156, 38042 Grenoble, France

6. European Spallation Source ERIC, P.O. Box 176, SE-221 00 Lund, Sweden

7. Lund Institute of Advanced Neutron and X-Ray Science, Scheelevägen 19, 223 70 Lund, Sweden

8. School of Chemical Engineering and Translational Nanobioscience Research Center, Sungkyunkwan University, Suwon, Republic of Korea

Abstract

We have investigated the interaction between a model system of DOPC/DLin-MC3-DMA, an ionisable lipid used in lipid nanoparticles for mRNA delivery, with different mRNAs and shown that the adsorption behaviour depends on the mRNA secondary structure.

Funder

Vetenskapsrådet

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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