Selective anticancer copper(ii)-mixed ligand complexes: targeting of ROS and proteasomes-Reference-Cited by-同舟云学术

Selective anticancer copper(ii)-mixed ligand complexes: targeting of ROS and proteasomes

Published:2014 Issue:4 Volume:6 Page:892-906
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Ng Chew Hee¹²³⁴,Kong Siew Ming⁵⁶⁷,Tiong Yee Lian⁸⁹³⁴,Maah Mohd Jamil¹⁰¹¹¹²,Sukram Nurhazwani¹³¹⁴¹⁵¹⁶,Ahmad Munirah¹³¹⁴¹⁵¹⁶,Khoo Alan Soo Beng¹³¹⁴¹⁵¹⁶

Affiliation:

1. Department of Pharmaceutical Chemistry

2. School of Pharmacy

3. International Medical University

4. 57000 Kuala Lumpur, Malaysia

5. Faculty of Science

6. Universiti Tunku Abdul Rahman

7. 31900 Kampar, Malaysia

8. School of Postgraduate Studies and Research

9. School of Medicine

10. Chemistry Department

11. University of Malaya

12. 50603 Kuala Lumpur, Malaysia

13. Molecular Pathology Unit

14. Cancer Research Centre

15. Institute for Medical Research

16. , Malaysia

Abstract

The ternary copper(ii) complexes 1–4 exhibited anticancer selectivity, as evidenced by MTT assay, % apoptosis, cell cycle arrest, ROS induction and DNA DSBs. Proteasome of cancer cells are also inhibited.

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MT/C3MT00276D

Reference59 articles.

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4. Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

5. Targeting ROS: Selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound

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