Synthesis of a dimeric 3α-hydroxy-7α,12α-diamino-5β-cholan-24-oate conjugate and its derivatives, and the effect of lipophilicity on their anion transport efficacy-Reference-Cited by-同舟云学术

Synthesis of a dimeric 3α-hydroxy-7α,12α-diamino-5β-cholan-24-oate conjugate and its derivatives, and the effect of lipophilicity on their anion transport efficacy

Published:2017 Issue:13 Volume:15 Page:2831-2840
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Li Zhi¹²³⁴⁵,Chen Yun¹²³⁴⁵,Yuan De-Qi⁶⁷⁸⁹,Chen Wen-Hua¹²³⁴⁵^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of New Drug Screening

2. School of Pharmaceutical Sciences

3. Southern Medical University

4. Guangzhou 510515

5. P. R. China

6. Faculty of Pharmaceutical Sciences

7. Kobe Gakuin University

8. Kobe 650-8586

9. Japan

Abstract

A dimeric 3α-hydroxy-7α,12α-diamino-5β-cholan-24-oate conjugate and its derivatives were synthesized, and lipophilicity was found to significantly affect their anion transport efficacy.

Funder

Program for New Century Excellent Talents in University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00289K

Reference59 articles.

1. Molecular Structure and Physiological Function of Chloride Channels

2. Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells