Iron deficiency exacerbates aortic medial degeneration by inducing excessive mitochondrial fission

Author:

Zhong Xiaohan123ORCID,Wu Qi123,Wang Zhiwei13ORCID,Zhang Min13,Zheng Sihao123,Shi Feng123,Chen Yuanyang123,Che Yanjia123,Yuan Shun123,Xing Kai123ORCID

Affiliation:

1. Department of Cardiothoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China

2. Cardiovascular Surgery Laboratory, Renmin Hospital of Wuhan University, 9# Zhangzhidong Road, Wuhan 430000, Hubei Province, People's Republic of China

3. Central Laboratory, Renmin Hospital of Wuhan University, 9# Zhangzhidong Road, Wuhan 430000, Hubei Province, People's Republic of China

Abstract

Iron deficiency disrupts energy metabolism in vascular smooth muscle cells, resulting in excessive mitochondrial fission and the acceleration of aortic media degeneration.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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