Antiepileptic drugs affect lipid oxidative markers- neuroprostanes and F2-dihomo-isoprostanes- in patients with epilepsy: differences among first-, second-, and third-generation drugs by UHPLC-QqQ-MS/MS-Reference-Cited by-同舟云学术

Antiepileptic drugs affect lipid oxidative markers- neuroprostanes and F2-dihomo-isoprostanes- in patients with epilepsy: differences among first-, second-, and third-generation drugs by UHPLC-QqQ-MS/MS

Published:2016 Issue:86 Volume:6 Page:82969-82976
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Medina Sonia¹²³⁴⁵,Carrasco-Torres Rubén⁶⁷⁵⁸,Amor Ma Isabel¹²³⁴⁵,Oger Camille⁹¹⁰¹¹¹²¹³,Galano Jean-Marie⁹¹⁰¹¹¹²¹³,Durand Thierry⁹¹⁰¹¹¹²¹³,Villegas-Martínez Irene⁶⁷⁵⁸,Auvin Stephane¹⁴¹⁵¹⁶¹⁷¹³,Ferreres Federico¹²³⁴⁵,Gil-Izquierdo Ángel¹²³⁴⁵

Affiliation:

1. Research Group on Quality

2. Safety and Bioactivity of Plant Foods

3. Department of Food Science and Technology

4. CEBAS (CSIC)

5. Murcia

6. Epilepsy Unit

7. University Hospital Virgen de la Arrixaca

8. Spain

9. Institut des Biomolécules Max Mousseron (IBMM)

10. UMR 5247 – CNRS – University of Montpellier – ENSCM

11. Faculty of Pharmacy

12. Montpellier

13. France

14. Department of Neuropediatric

15. Robert Debré Hospital

16. APHP

17. Paris

Abstract

This work show that treatment with new-generation AEDs reduces the excretion of NeuroPs/F₂-dihomo-IsoPs to values similar to those in the control group, indicating a positive effect of these AEDs on the antioxidant status of epileptic patients.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA15777G

Reference44 articles.

1. New avenues for anti-epileptic drug discovery and development

2. Blood Levels of Trace Elements, Electrolytes, and Oxidative Stress/Antioxidant Systems in Epileptic Patients

3. Antiepileptic drugs in epilepsy and other disorders—A population-based study of prescriptions

4. Free radicals, anticonvulsants, and the neuronal ceroid-lipofuscinoses

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