Synthesis of aza and carbocyclic β-carbolines for the treatment of alcohol abuse. Regiospecific solution to the problem of 3,6-disubstituted β- and aza-β-carboline specificity
Author:
Affiliation:
1. Department of Chemistry and Biochemistry
2. University of Wisconsin-Milwaukee
3. Milwaukee
4. USA
5. Center for Bimolecular Science and Engineering
6. Naval Research Laboratory
7. Washington
Abstract
A novel two step protocol was developed to gain regiospecific access to 3-substituted β- and aza-β-carbolines, 3-PBC (1), 3-ISOPBC (2), βCCt (3), 6-aza-3-PBC (4) and 6-aza-3-ISOPBC (5).
Funder
National Institute on Alcohol Abuse and Alcoholism
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01572C
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