Rational design of engineered H-ferritin nanoparticles with improved siRNA delivery efficacy across an <i>in vitro</i> model of the mouse BBB-Reference-Cited by-同舟云学术

Rational design of engineered H-ferritin nanoparticles with improved siRNA delivery efficacy across an in vitro model of the mouse BBB

Published:2022 Issue:17 Volume:14 Page:6449-6464
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Yuan Ziwei¹,Wang Bin¹,Teng Yilong¹,Ho William²,Hu Bin¹,Boakye-Yiadom Kofi Oti¹,Xu Xiaoyang²^ORCID,Zhang Xue-Qing¹^ORCID

Affiliation:

1. Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China

2. Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA

Abstract

This work presents a simple yet elegant siRNA encapsulation approach based on arginine mutations on the inner surface of HFn, offering insights into the development of biomimic nanoaparticles for the delivery of siRNA therapeutics to the brain.

Funder

Shanghai Jiao Tong University

Gustavus and Louise Pfeiffer Research Foundation

American Heart Association

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D1NR07880A

Reference61 articles.