A unique activation–promotion mechanism of the influenza B M2 proton channel uncovered by multiscale simulations
Author:
Affiliation:
1. Laboratory of Theoretical and Computational Chemistry
2. Institute of Theoretical Chemistry
3. International Joint Research Laboratory of Nano-Micro Architecture Chemistry
4. Jilin University
5. Changchun 130023
Abstract
Our simulations proposed a unique activation-promotion mechanism for the BM2 channel which hasn’t been reported in other similar proton channels.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2019/CP/C9CP00130A
Reference44 articles.
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3. Structure and mechanism of the M2 proton channel of influenza A virus
4. Structural basis for the function and inhibition of an influenza virus proton channel
5. Solution structure and functional analysis of the influenza B proton channel
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