A DNA-modified hydrogel for simultaneous purification, concentration and detection of targeted cfDNA in human serum-Reference-Cited by-同舟云学术

A DNA-modified hydrogel for simultaneous purification, concentration and detection of targeted cfDNA in human serum

Published:2019 Issue:6 Volume:9 Page:3407-3415
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Jiang Xinglu¹²³,Zhao Chenggui⁴⁵⁶²³,Fan Xiaobo¹²³,Xu Wei¹²³,Zhang Rui¹²³,Xu Hongbo¹²³,Wu Guoqiu¹²³⁴⁵^ORCID

Affiliation:

1. Medical School of Southeast University

2. Nanjing 210009

3. People's Republic of China

4. Center of Clinical Laboratory Medicine

5. Zhongda Hospital

6. Southeast University

Abstract

A cost-effective device based on DNA-modified polyacrylamide hydrogel was designed to simultaneously catch, purify, concentrate, and detect targeted cfDNA by electrophoresis at low concentrations with high specificity and selectivity.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C8RA10138H

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