Peramivir analogues bearing hydrophilic side chains exhibit higher activities against H275Y mutant than wild-type influenza virus-Reference-Cited by-同舟云学术

Peramivir analogues bearing hydrophilic side chains exhibit higher activities against H275Y mutant than wild-type influenza virus

Published:2017 Issue:46 Volume:15 Page:9910-9922
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Chiu Din-Chi¹²³⁴^ORCID,Lin Tzu-Chen¹²³⁴,Huang Wen-I⁵⁶⁷⁴,Cheng Ting-Jen⁵⁶⁷⁴,Tsai Keng-Chang⁸⁹¹⁰⁴¹¹,Fang Jim-Min¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. National Taiwan University

3. Taipei 106

4. Taiwan

5. The Genomics Research Center

6. Academia Sinica

7. Taipei 115

8. National Research Institute of Chinese Medicine

9. Ministry of Health and Welfare

10. Taipei 112

11. The Ph.D. Program for Medical Biotechnology

Abstract

The peramivir analogue bearing a hydrophilic glycerol side chain displays 9-fold stronger inhibition against H275Y mutant than wild-type influenza virus.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB02374J

Reference31 articles.

1. The Pathology of Influenza Virus Infections

2. Zanamivir

3. Zanamivir: from drug design to the clinic

4. Rational design of potent sialidase-based inhibitors of influenza virus replication

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