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An approach to enzyme inhibition employing reversible boronate ester formation

Published:2011 Issue:5 Volume:2 Page:390
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Leung Ivanhoe K. H.,Brown Jr Tom,Schofield Christopher J.,Claridge Timothy D. W.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2011/MD/C1MD00011J

Reference44 articles.

1. Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications

2. Boronic acid compounds as potential pharmaceutical agents

3. Serine Protease Mechanism and Specificity

4. X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state.

5. Kinetic properties of the binding of .alpha.-lytic protease to peptide boronic acids

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