Homopurine RP-stereodefined phosphorothioate analogs of DNA with hampered Watson–Crick base pairings form Hoogsteen paired parallel duplexes with (2′-OMe)-RNAs-Reference-Cited by-同舟云学术

Homopurine RP-stereodefined phosphorothioate analogs of DNA with hampered Watson–Crick base pairings form Hoogsteen paired parallel duplexes with (2′-OMe)-RNAs

Published:2019 Issue:18 Volume:17 Page:4611-4620
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Maciaszek Anna¹²³⁴⁵^ORCID,Jastrzębska Katarzyna¹²³⁴⁵^ORCID,Guga Piotr¹²³⁴⁵^ORCID

Affiliation:

1. Centre of Molecular and Macromolecular Studies

2. Polish Academy of Sciences

3. Department of Bioorganic Chemistry

4. 90-363 Łódź

5. Poland

Abstract

At pH 7.2, N⁶-methyl-dA units present in homopurine R_P-stereodefined PS-DNA oligomers stabilize Hoogsteen paired duplexes with (2′-OMe)-RNA matrices by 3 °C per modified unit.

Funder

Narodowe Centrum Nauki

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB03112F

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1. 42.16.4 Phosphoric Acid and Derivatives (Update 2021);Knowledge Updates 2021/1;2021

2. LNA units present in [RP-PS]-(DNA#LNA) chimeras enhance the thermal stability of parallel duplexes and triplexes formed with (2′-OMe)-RNA strands;RSC Advances;2020