Site-selective peptide functionalisation mediated <i>via</i> vinyl-triazine linchpins-Reference-Cited by-同舟云学术

Site-selective peptide functionalisation mediated via vinyl-triazine linchpins

Published:2024 Issue:6 Volume:60 Page:706-709
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Sydenham Jack D.¹^ORCID,Seki Hikaru¹^ORCID,Krajcovicova Sona¹²^ORCID,Zeng Linwei¹^ORCID,Schober Tim¹,Deingruber Tomas¹^ORCID,Spring David R.¹^ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

2. Department of Organic Chemistry, Palacky University in Olomouc, Tr. 17. Listopadu 12, Olomouc, Czech Republic

Abstract

1,2,4-vinyl-triazines were found to be cysteine selective bioconjugation reagents which could then perform a inverse electron demand Diels Alder (IEDDA) reaction that was selective for bicyclononyne (BCN) over Dibenzocyclooctyne-acid (DBCO).

Funder

EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis

Horizon 2020 Framework Programme

Grantová Agentura České Republiky

UK Research and Innovation

Isaac Newton Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D3CC05213C

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